Glycosyl compounds
Medchemexpress LLC N-(benzyloxycarbonyl)-D-leucine | 28862-79-5 | MFCD00066068 | 99.1% | 265.30 g/mol | C14H19NO4 | 100g
D-N-(Benzyloxycarbonyl)leucine is a leucine derivative[1]
Sigma Aldrich Fine Chemicals Biosciences 5-Bromo-4-chloro-3-indolyl beta-D-glucuronide sodium salt >=98% | 129541-41-9 | MFCD00135782 | 25MG
5-Bromo-4-chloro-3-indolyl beta-D-glucuronide sodium salt >=98% | Purity: >=98% | Mol Wt: 444.59 | 129541-41-9 | MFCD00135782 | 25MG
Medchemexpress LLC Schisantherin D | 64917-82-4 | 1 MG
Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. It exhibits anti-HIV replication activities with an EC50 of 0.5 μg/mL. Additionally, Schisantherin D inhibits endothelin receptor B (ETBR) and possesses hepatoprotective effects. It is intended for research use only.
- Exhibits anti-HIV replication activity
- Inhibits endothelin receptor B (ETBR)
- Possesses hepatoprotective effects
- Isolated from Schisandra sphenanthera
- High purity of 99.66%
Cayman Chemical n-DodecylD-maltosIde 500mg
A non-ionic detergent commonly used to solubilize membrane-associated proteins; helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation
Apexbio Technology LLC ISRIB (trans-isomer) 1597403-47-8 10mM (in 1mL DMSO)
ISRIB (trans-isomer) (CAS 1597403-47-8) is a small molecule inhibitor of the integrated stress response (ISR) ISR activation involves the phosphorylation of eukaryotic initiation factor 2 (eIF2 ) by stress-sensitive kinases leading to reduced global protein synthesis and enhanced translation of select mRNAs ISRIB counteracts ISR signaling by reversing the translational suppression induced by phosphorylated eIF2 inhibiting production of ATF4 protein decreasing stress granule assembly and promoting polyribosome formation during endoplasmic reticulum (ER) stress ISRIB stabilizes and activates eIF2B by facilitating its dimerization Rodent studies demonstrate ISRIB s capacity to enhance hippocampal-dependent spatial and fear-related learning and memory highlighting its utility in neuroscience research
Medchemexpress LLC D-3263 hydrochloride | 1008763-54-9 | 98.12% | 409.95 | 100 MG
D-3263 hydrochloride is an enteric-coated, orally bioavailable transient receptor potential melastatin member 8 (TRPM8) agonist. It binds to and activates TRPM8, which may lead to an increase in calcium and sodium entry, disruption of calcium and sodium homeostasis, and induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may also decrease dihydrotestosterone (DHT) levels, potentially contributing to its inhibitory effects on prostate cancer and benign prostatic hyperplasia (BPH).
- Binds to and activates TRPM8.
- Increases calcium and sodium entry into cells.
- Disrupts calcium and sodium homeostasis.
- Induces cell death in TRPM8-expressing tumor cells.
- Decreases dihydrotestosterone (DHT) levels.
- Inhibits prostate cancer and benign prostatic hyperplasia (BPH).
Medchemexpress LLC (D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) | 18067-65-7 | >99.9% | 2933.44 | 5 MG
(D-Ser1)-ACTH (1-24) is an adrenocorticotropic hormone (ACTH) analogue. It requires specific storage conditions to maintain stability.
- Suitable for sealed storage, away from moisture.
- Powder can be stored at -80°C for 2 years or -20°C for 1 year.
- In solvent, it can be stored at -80°C for 6 months or -20°C for 1 month.
Apexbio Technology LLC Trehalose(Synonyms: Mycose, α,α-Trehalose, alpha-D-glucopyranosyl-alpha-D-glucopyranoside), 500mg, CAS: 99-20-7.
Trehalose (CAS 99-20-7) isolated from Saccharomyces cerevisiae is a non-reducing disaccharide composed of two -glucose units connected by an -1 1-glucosidic linkage It enhances cellular resistance to stress factors such as dehydration and cryopreservation however mammalian cells require intracellular presence of trehalose which is limited by low membrane permeability due to its hydrophilic non-ionic nature Derivatization strategies (e g acetylation) to increase membrane traversal may enable the application of trehalose in biopreservation and cytoprotection research
Apexbio Technology LLC D-(-)-Salicin 138-52-3 10mM (in 1mL DMSO)
D-(-)-Salicin (CAS 138-52-3) is a -glucoside compound isolated from the purple willow (Salix spp ) Upon enzymatic hydrolysis it releases saligenin which is subsequently oxidized to salicylic acid a known modulator of inflammatory pathways through cyclooxygenase (COX) inhibition D-(-)-Salicin is utilized in biomedical research to investigate anti-inflammatory mechanisms pain modulation and metabolic conversion of glycosides It is soluble in boiling water alkaline solutions pyridine and acetic acid For optimal stability the compound should be stored in a sealed container under cool dry conditions
Cayman Chemical n-Dodecyl-a-D-maltosIde 500mg
A nonionic detergent commonly used to solubilize integral membrane proteins and protein complexes; CMC = 0.15 mM; has been used to solubilize PSI and PSII complexes from plant thylakoid membranes, as well as intact grana
Medchemexpress LLC Diethylstilbestrol-d8 | 91318-10-4 | MFCD01074086 | 99.7% | C18H12D8O2 | 1 MG
Diethylstilbestrol-d8 is the deuterium labeled version of Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be utilized as a tracer
- Can be utilized as an internal standard for quantitative analysis
- Quantitative analysis methods include NMR, GC-MS, or LC-MS
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development
Medchemexpress LLC VEGF-D Rat HEK293 1mg
VEGF-D a growth factor stimulates proliferation migration and vessel permeability It is crucial for vascular development and maintenance of lymphatic endothelium VEGF-D binds and activates VEGFR-3 initiating essential signaling pathways Structurally it forms a non-covalent homodimer playing an intricate role in vascular processes VEGF-D Protein Rat (HEK293 Fc) is the recombinant rat-derived VEGF-D protein expressed by HEK293 with N-hFc labeled tag
Apexbio Technology LLC Methyl α-D-mannopyranoside 617-04-9 25g
Methyl alpha-D-mannopyranoside (CAS 617-04-9) is a small-molecule ligand targeting mannose receptors expressed on macrophages It is designed to bind selectively to these receptors thereby facilitating internalization and intracellular delivery of conjugated therapeutic agents Methyl alpha-D-mannopyranoside exerts its biological activity primarily through specific binding to macrophage mannose receptors enabling targeted transport into macrophages Studies evaluating receptor binding report IC50 values generally ranging from micromolar to millimolar levels depending on experimental conditions and assay methods Based on these pharmacological properties methyl alpha-D-mannopyranoside holds research potential in targeted drug delivery for anti-tubercular therapies